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Charles D Smith Selected Research

Carcinoma (Carcinomatosis)

12/2011Combined anticancer effects of sphingosine kinase inhibitors and sorafenib.
3/2011Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.
5/2010A novel sphingosine kinase inhibitor induces autophagy in tumor cells.

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Charles D Smith Research Topics

Disease

54Neoplasms (Cancer)
05/2024 - 01/2003
14Inflammation (Inflammations)
02/2024 - 11/2006
8Alzheimer Disease (Alzheimer's Disease)
01/2019 - 06/2006
7Dementia (Dementias)
10/2014 - 11/2004
6Cognitive Dysfunction
01/2017 - 07/2009
5Muscular Diseases (Myopathy)
01/2021 - 06/2006
5Frontotemporal Dementia (Semantic Dementia)
01/2021 - 06/2006
5Prostatic Neoplasms (Prostate Cancer)
12/2015 - 07/2008
5Parkinson Disease (Parkinson's Disease)
01/2015 - 02/2005
4Melanoma (Melanoma, Malignant)
11/2023 - 03/2005
4Osteitis Deformans (Paget's Disease of Bone)
01/2021 - 06/2006
4Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia
01/2021 - 06/2006
4Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
07/2015 - 06/2006
4Adenocarcinoma
12/2011 - 04/2010
3Ischemia
01/2022 - 01/2012
3Carcinogenesis
01/2017 - 03/2005
3Neurodegenerative Diseases (Neurodegenerative Disease)
01/2016 - 06/2006
3Lymphoma (Lymphomas)
09/2015 - 01/2009
3Hypoxia (Hypoxemia)
11/2013 - 01/2012
3Arthritis (Polyarthritis)
10/2013 - 03/2009
3Carcinoma (Carcinomatosis)
12/2011 - 05/2010
3Breast Neoplasms (Breast Cancer)
04/2011 - 06/2008
3Hematologic Neoplasms (Hematological Malignancy)
01/2011 - 06/2009
3Disease Progression
04/2010 - 07/2005
2COVID-19
05/2024 - 01/2022
2Lung Neoplasms (Lung Cancer)
11/2023 - 01/2018
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2018 - 07/2011
2Epilepsy (Aura)
07/2015 - 10/2005
2Hippocampal Sclerosis
07/2015 - 05/2011
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
10/2013 - 04/2008
2Hepatocellular Carcinoma (Hepatoma)
08/2011 - 03/2011
2Giardiasis
08/2011 - 08/2011
2Colonic Neoplasms (Colon Cancer)
08/2011 - 10/2010
2Weight Loss (Weight Reduction)
11/2010 - 01/2003
2Leukemia
06/2009 - 01/2009
1Neuroblastoma
05/2024
1Fibrosis (Cirrhosis)
02/2024
1Pneumonia (Pneumonitis)
02/2024
1Pathologic Processes
01/2022

Drug/Important Bio-Agent (IBA)

243- (4- chlorophenyl)- adamantane- 1- carboxylic acid (pyridin-4-ylmethyl)amideIBA
02/2024 - 04/2010
18Proteins (Proteins, Gene)FDA Link
05/2024 - 04/2004
18sphingosine kinaseIBA
01/2022 - 09/2003
17SphingosineIBA
02/2024 - 01/2011
14SphingolipidsIBA
05/2024 - 11/2010
12Phosphotransferases (Kinase)IBA
11/2023 - 03/2005
12Sorafenib (BAY 43-9006)FDA Link
04/2016 - 08/2006
10sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
11/2023 - 11/2011
8EnzymesIBA
02/2024 - 09/2003
8CeramidesIBA
11/2023 - 06/2008
7Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2018 - 11/2006
7Biomarkers (Surrogate Marker)IBA
01/2017 - 06/2006
4Protein Kinases (Protein Kinase)IBA
01/2018 - 01/2009
4Small Interfering RNA (siRNA)IBA
10/2013 - 03/2005
4Member 1 Subfamily B ATP Binding Cassette TransporterIBA
07/2011 - 01/2003
4ApolipoproteinsIBA
05/2011 - 03/2006
3AntibodiesIBA
05/2024 - 01/2013
3Interleukin-6 (Interleukin 6)IBA
02/2024 - 05/2013
3UbiquitinIBA
01/2021 - 06/2006
3Indicators and Reagents (Reagents)IBA
01/2017 - 07/2011
3Hormones (Hormone)IBA
01/2015 - 04/2011
3Doxorubicin (Adriamycin)FDA LinkGeneric
08/2011 - 01/2003
3Mitogen-Activated Protein KinasesIBA
06/2008 - 03/2005
3Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
04/2007 - 02/2005
3Valosin Containing ProteinIBA
02/2007 - 06/2006
2Irinotecan (Camptosar)FDA LinkGeneric
05/2024 - 08/2011
2Temozolomide (Temodar)FDA LinkGeneric
05/2024 - 10/2017
2dihydroceramide desaturaseIBA
02/2024 - 12/2015
2Investigational DrugsIBA
02/2024 - 11/2023
2Cisplatin (Platino)FDA LinkGeneric
10/2022 - 07/2011
2IsoenzymesIBA
01/2018 - 11/2011
2Telomerase (Telomerase Reverse Transcriptase)IBA
01/2018 - 06/2015
2CytokinesIBA
01/2018 - 01/2012
2GemcitabineFDA Link
09/2016 - 08/2011
2Eosine Yellowish-(YS) (Eosin)IBA
07/2015 - 05/2011
2Phosphates (Orthophosphate)IBA
01/2015 - 11/2011
2Messenger RNA (mRNA)IBA
01/2012 - 07/2006
2Fluorouracil (Carac)FDA LinkGeneric
08/2011 - 08/2011
2Quinacrine (Mepacrine)IBA
08/2011 - 08/2011
2Antimitotic AgentsIBA
07/2011 - 07/2007
2DNA (Deoxyribonucleic Acid)IBA
07/2011 - 05/2011
2proto-oncogene proteins pimIBA
01/2011 - 01/2010
2Serine (L-Serine)FDA Link
01/2011 - 01/2010
2Threonine (L-Threonine)FDA Link
01/2011 - 01/2010
2Dextran SulfateIBA
10/2010 - 04/2008
2Apolipoprotein E4IBA
10/2010 - 07/2010
2Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
05/2010 - 01/2007
2olsalazine (Dipentum)FDA Link
04/2010 - 04/2008
2DNA-Binding Proteins (DNA Binding Protein)IBA
07/2009 - 02/2007
2Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
06/2008 - 08/2006
2Apolipoproteins E (ApoE)IBA
01/2007 - 03/2006
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2006 - 03/2005
2N- 1- benzyl- 2,3- dihydro- 1H- pyrrolo(2,3- b)quinolin- 4- yl- 2- phenylacetamideIBA
03/2004 - 01/2003
1N-Myc Proto-Oncogene ProteinIBA
05/2024
1CalreticulinIBA
11/2023
1Antiviral Agents (Antivirals)IBA
01/2022

Therapy/Procedure

15Therapeutics
05/2024 - 07/2005
9Drug Therapy (Chemotherapy)
11/2023 - 01/2003
4Oral Administration
01/2018 - 04/2010
3Radiotherapy
02/2024 - 10/2007
1Nephrectomy
01/2022